Study on the Effect of Self-Designed Chloasma Dispelling Capsule and its Functional Components on Melasma Model Mice
Objective To study the effects of Carthami Flos,Angelicae Sinensis Radix,Persicae Semen extract and self-de-signed chloasma dispelling capsule on mice with melasma induced by progesterone injection and ultraviolet irradiation.Meth-ods Mouse melasma model was established by injection of progesterone and UV irradiation for 30 days.At the end of different do-ses,the relevant indexes in serum,liver homogenate and skin tissue of mice were detected.At the same time,the number of skin melanocytes was observed.Results Compared with model group,except Angelicae Sinensis Radix extract two dose groups,the other dose groups could increase the activity of superoxide dismutase in serum,liver and skin tissue of melasma model mice,reduce the contents of malondialdehyde and tyrosinase(P＜0.05 or P＜0.01),and reduce the content of lipofuscin in liver and skin tissue(P＜0.05 or P＜0.01);Compared with the model group,the high dose group of Angelicae Sinensis Radix could increase the ac-tivity of superoxide dismutase and reduce the content of tyrosinase in serum,liver and skin tissue of melasma model mice(P＜0.05).The activity of superoxide dismutase and tyrosinase content in liver and lipofuscin in skin tissue of the Angelicae Sinensis Radix low-dose group were significantly different from those of the model group(P＜0.05).Compared with the model group,the self-designed chloasma dispelling capsule high-dose and low-dose groups could significantly reduce the number of mela-nocytes in the skin tissue at the irradiated site(P＜0.05orP＜0.01),and the Carthami Flos extract high-dose group could also significantly reduce the number of melanocytes in the skin tissue at the irradiated site(P＜0.05).The number of melanocytes in the skin tissue of the other groups and the model group decreased,but there was no statistical difference.Conclusion The extracts of Carthami Flos,Angelicae Sinensis Radix,Persicae Semen and self-designed chloasma dispelling capsule have certain protec-tive effects on melasma model mice and can play the function of removing melasma,and the combination of three extracts has syn-ergistic effect.
万方数据
维普
