Irritable bowel syndrome is a common clinical digestive system disease,with abdominal pain and diarrhea as the main symptom.The pathogenesis is mainly increased visceral sensitivity and intestinal permeability.Increased visceral sensitivity can be divided into central and peripheral properties.Peripheral sensitization refers to abnormal intestinal,autonomic afferents and DRG signaling,central sensitization refers to sensitization of dorsal horn neurons in the spinal cord and abnormal processing of afferent signals at the brain.Clinical external peripheral sensitization mainly.Through a large review of relevant literature,TRPV 1 signaling pathway was found as one of the main signaling pathways for the treatment of irritable bowel syndrome.After TRPV 1 is activated,Ca2+mobility inside and outside the cells is changed,increasing the sensitivity of internal tissues and or-gans,and making the body produce hyperalgesia and pathological pain.This paper integrates and summarizes relevant studies at home and abroad,aiming to provide therapeutic research basis for the clinical treatment of IBS-D,in order to provide new ideas for the treatment of IBS-D in TCM.
关键词
瞬时受体电位通道香草素亚型1信号通路/肠易激综合征/内脏敏感性/腹痛/中医药
Key words
TRPV1,signaling pathway/irritable bowel syndrome/visceral sensitivity/abdominal pain/traditional Chinese medicine
维普
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