Meta-Analysis and Sequential Analysis of Efficacy and Safety of Yangxueqingnao Particles Combined with Conventional Medical Therapy in the Treatment of Tension-Type Headache
Objective To systematically assess the efficacy and safety of Yangxueqingnao particles combined with conventional medical therapy in the treatment of Tension-type headache(TTH).Method Retrieved Chinese and English databases,including CNKI,Wanfang,PubMed,Embase and so on,to screen out randomized controlled trials(RCT)for modified Yangxueqingnao parti-cle combined with conventional medical therapy in the treatment of TTH from the establishment of databases to July 2021.The Cochrane system evaluation method was used to assess the quality of the literature.RevMan 5.3 was used for Meta-analysis,and TSA 0.9.5.10 Beta software was adopted for test sequential analysis.Results A total of 27 RCT were included,involving 2905 patients.The results of Meta-analysis reflected that,compared with the control group,The total effective rate was signifi-cantly better than the control group[OR=6.80,95％CI=(5.31,8.71),P＜0.000 01],headache severity decreased(MD=-1.05,95％CI[-1.37,-0.74],P＜0.000 01),headache duration reduced(MD=-26.93,95％CI[-38.54,-15.31],P＜0.000 01),the number of headache attacks reduced(MD=-1.64,95％CI[-2.47,-0.80],P=0.000 1),the first headache disappear time reduced(MD=-6.56,95％CI[-9.37,-3.76],P＜0.000 01)and the fifth headache disappear time reduced(MD=-9.01,95％CI[-11.73,-6.29],P＜0.000 01).Meanwhile,there were no serious adverse events dur-ing the study,and Yangxueqingnao particles showed good safety.Test sequential analysis further clarified the effect of Yangx-ueqingnao particles combined with conventional medical therapy on the TTH,excluding false positive.Conclusion Yangxueqing-nao particles combined with conventional medical therapy has a better effect than the control group on the treatment of chronic heart failure,and shows a good safety profile.Considering the limited quality of the included studies,more high quality RCT are needed to further verify the conclusion.
万方数据
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