A Meta-Analysis of Integrated Traditional Chinese and Western Medicine in Improving Hemodynamics of Chronic Heart Failure
Objective To systematically evaluate the efficacy and safety of integrated traditional Chinese and western medicine in improving hemodynamic indexes in patients with chronic heart failure.Methods From January 1,2018 to March 1,2023,Chi-na National Knowledge Infrastructure(CNKI),Wanfang,VIP,PubMed,Cochrane Library and Embase were searched for clini-cal studies on hemodynamics of integrated traditional Chinese and Western medicine in the treatment of chronic heart failure,and literature information was extracted to establish a database.All monitoring hemodynamic methods and indicators in the literature were summarized,and meta-analysis was performed using Review Manager5.4.1 software.Results Meta analysis results:A to-tal of 23 articles were included,involving 2365 patients,including 1186 patients in the experimental group and 1179 patients in the control group.Meta showed that the main outcome index was the total effective rate of hemodynamic indexes improved by in-tegrated traditional Chinese and western medicine in patients with chronic heart failure(RR=1.23,95％CI:1.19,1.28,P＜0.001),suggesting that the combination of traditional Chinese and western medicine improved the hemodynamic parameters of patients with chronic heart failure,and the secondary outcome was cardiac output(RR=1.25,95％CI:1.18,1.32,P＜0.001),cardiac index(RR=1.25,95％CI:1.18,1.32,P＜0.001),peripheral resistance(RR=1.21,95％CI:1.14,1.28,P＜0.001),stroke volume(RR=1.23,95％CI:1.15,1.32,P＜0.001),heart rate(RR=1.25,95％CI:1.14,1.38,P＜0.001),peripheral blood pressure(RR=1.28,95％CI:1.14,1.44,P＜0.001),cardiac contractility index(RR=1.18,95％CI:1.10,1.27,P＜0.001),left ventricular ejection fraction(RR=1.26,95％CI:1.13,1.40,P＜0.001),thoracic fluid volume(RR=1.25,95％CI:1.12,1.40,P＜0.000 1).Number of occurrences of hemodynamic indicators>The three times were cardiac output(47.8％),cardiac index(47.8％),peripheral resistance(43.5％),stroke volume(39.1％),heart rate(26.1％),peripheral blood pressure(17.4％),cardiac contractility index(13.1％),left ventricular e-jection fraction(13.1％),and thoracic fluid volume(13.1％).Conclusion Compared with simple western medicine treatment,combined traditional Chinese and western medicine treatment can improve the hemodynamics of chronic heart failure,increase cardiac output,cardiac index,stroke volume,cardiac contractility index,left ventricular ejection fraction,and reduce peripheral blood pressure,heart rate,peripheral resistance,and thoracic fluid volume.Hemodynamic indices commonly used are cardiac output,cardiac index,peripheral resistance,stroke volume,heart rate,peripheral blood pressure,cardiac contractility index,left ventricular ejection fraction,and thoracic fluid volume.
integrated traditional Chinese and western medicine treatmentchronic heart failurehemodynamicsMeta anal-ysis
万方数据
维普
