Exploring the Relationship Between Intestinal Flora and Insomnia Based on the Theory of"Two Poles,One Pivot"
Sleeplessness is a disease clinically characterized by frequent difficulties in falling asleep or maintaining sleep,and causing serious burdens to daily work and life.Currently,a large number of studies have proved that the imbalance between the a-bundance and quantity of metabolites of intestinal flora is one of the key triggers for the development of insomnia.Traditional Chi-nese medicine(TCM)has always had a unique advantage in the prevention and treatment of mood disorders,so this article starts from the holistic concept of TCM and takes the"two poles and one hub"composed of the heart-kidney-spleen hub as the entry point to review the microecological imbalance of the intestinal tract and the pathogenesis of insomnia,in order to clarify the mech-anism of the metabolites of the intestinal flora involved in the insomnia,and provide a reference for the treatment of TCM or drug research.We hope to clarify the role of intestinal flora metabolites in insomnia and provide reference for Chinese medicine treat-ment or drug research.
insomniaintestinal florabipolar one centerheart-spleen-kidney
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