Alzheimer's disease(AD)is characterized by progressive memory loss,and the main pathogenetic hypotheses are the β-amyloid(Aβ)waterfall hypothesis and the tau protein hypothesis.In traditional Chinese medicine,kidney is more impor-tant than spleen for AD.Spleen and stomach are the basis for the function of other organs,so spleen Qi benefiting transportation is of great importance for the treatment of AD.Modern research has found that ferroptosis affects the development of AD through i-ron metabolism disorders,lipid peroxidation,glutathione depletion and glutathione peroxidase.The mechanism of spleen dysfunc-tion is similar to that of ferroptosis leading to AD.In this article,it took spleen and stomach as an important entry point,and dis-cussed the mechanism of"spleen dysfunction-ferroptosis"in AD from the perspective of ferroptosis and emphasized the impor-tance of spleen and stomach in AD,aiming to provide theoretical support for spleen and stomach treating AD in the direction of ferroptosis.
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