Research Progress on Traditional Chinese Medicine Intervention in Notch signaling Pathway Regulation of Th17/Treg Immune Balance in Treatment of Autoimmune Thyroiditis
Notch signaling pathway,as a novel target mediating the regulation of Th17/Treg immune balance,plays a crucial role in immune system diseases,especially in thyroid diseases.In recent years,traditional Chinese medicine has unique advanta-ges in the treatment of Autoimmune Thyroiditis(AIT).A variety of Chinese medicine compounds have been proved to regulate Th17/Treg immune balance and prevent AIT by intervening in the notch signaling pathway.However,existing studies often only discuss the therapeutic effects of traditional Chinese medicine on AIT based on immune balance mechanism.There are few stud-ies on the intervention of TCM compounds in notch signaling pathway to regulate Th17/Treg immune balance in the treatment of AIT,which can further clarify the target of the treatment of AIT with Chinese medicine and provide medication ideas for the treat-ment of traditional Chinese medicine.In addition,there are many TCM compounds,which often play a therapeutic role through multiple pathways and mechanisms.Whether the pathways affect each other needs to be further discussed,and the specific mech-anism of action needs to be clarified.In-depth study on the regulation of Th17/Treg immune balance based on notch signaling pathway in the treatment of AIT can provide a new strategy for traditional Chinese medicine to improve the inflammatory immune microenvironment of AIT.
Notch signaling pathwayTh17/Treg immune balanceautoimmune thyroiditistraditional Chinese medicine
万方数据
维普
