Objective:To observe the effect of Jiuwei Yinao Granule combined with mouse nerve growth factor in the treatment of delayed encephalopathy after carbon monoxide poisoning(DEACMP).Methods:Eighty cases were randomly divided into two groups,with 40 cases in each group.Both groups were treated with mouse nerve growth factor,and the experimental group were treated with Jiuwei Yinao Granules in addition.Results:After treatment,the total effective rate,BDNF level and MoCA score of the experimental group were higher than those of the control group while the scores of mental disorder,dementia,limb tremor,vomiting,phlegm and saliva,miR-124 and 5-HT levels and CCS score were lower than those of the control group(P<0.05).The CCS scores of mental disorders,dementia,speechlessness,limb tremor,vomiting,phlegm and saliva,mir-124 and 5-HT levels in the two groups decreased,and those in the experimental group were lower than the control group(P<0.05).Conclusion:Jiuwei Yinao Granules combined with mouse nerve growth factor is effective in the treatment of delayed encephalopathy after carbon monoxide poisoning.