Objective:To observe the therapeutic effect of South Shaolin tendon-soothing maneuver combined with Huoluo Powder in the treatment of chronic ankle sprain.Methods:Sixty-five patients were randomly divided into a treatment group(33 patients)and a control group(32 patients).The treatment group received South Shaolin tendon-soothing maneuver and external application of Huoluo Powder,while the control group received ultrasound therapy and external application of Huoluo Powder.Results:After treatment,the Visual Analog Scale(VAS)scores decreased and ankle function scores increased in both groups(P<0.05),with the treatment group showing better improvement than the control group(P<0.05).The total effective rate was higher in the treatment group compared to the control group(P<0.05).Conclusion:South Shaolin tendon-soothing maneuver combined with external application of Huoluo Powder is effective in the treatment of chronic ankle sprain.