摘要
目的 以壳聚糖和黄芪多糖为原材料,制备羧甲基壳聚糖/黄芪多糖水凝胶.方法 通过加入Ca2+改善水凝胶的性能,通过总糖含量测定、单糖组成分析、红外光谱等对黄芪多糖进行理化性质分析;通过溶胀率、降解率、扫描电镜、剪切应变力性能的测定以及药物的释放量表征水凝胶.结果 羧甲基壳聚糖-黄芪多糖水凝胶(CMC-ARO)具有良好的生物可降解性能、多孔结构以及对药物的控释效果和低细胞毒性,加入低浓度的Ca2+能显著影响水凝胶的性能.结论 表明制备的水凝胶在药物传递系统、伤口愈合以及组织工程材料方面有应用的潜力.
Abstract
Objective Carboxymethyl chitosan and Astragalus polysaccharide hydrogel was prepared with chitosan and Astragalus polysaccharide as raw materials.Methods The properties of hydrogel were improved by adding proper amount of Ca2+.The phys-ical and chemical properties of Astragalus polysaccharides were analyzed by methods of total sugar content determination,mono-saccharide composition analysis and infrared spectrum.The hydrogel was characterized through swelling rate,degradation rate,scanning electron microscopy,shear strain force performance and drug release amount.Results The results showed the Astragalus polysaccharide-carboxymethyl chitosan(CMC-ARO)had significant biodegradability,porous structure,controlled drug release effect and low cytotoxicity,adding low concentration of Ca2+can significantly affect the properties of the gel.Conclusion The pre-pared water gel has potential applications in drug delivery systems,wound healing,and tissue engineering materials.
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