Objective Carboxymethyl chitosan and Astragalus polysaccharide hydrogel was prepared with chitosan and Astragalus polysaccharide as raw materials.Methods The properties of hydrogel were improved by adding proper amount of Ca2+.The phys-ical and chemical properties of Astragalus polysaccharides were analyzed by methods of total sugar content determination,mono-saccharide composition analysis and infrared spectrum.The hydrogel was characterized through swelling rate,degradation rate,scanning electron microscopy,shear strain force performance and drug release amount.Results The results showed the Astragalus polysaccharide-carboxymethyl chitosan(CMC-ARO)had significant biodegradability,porous structure,controlled drug release effect and low cytotoxicity,adding low concentration of Ca2+can significantly affect the properties of the gel.Conclusion The pre-pared water gel has potential applications in drug delivery systems,wound healing,and tissue engineering materials.
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