Research of Acute Toxicity for Danyu Hemai granules in Mice
Objective To observe the acute toxicity of Danyu Hemai granules in mice.Methods After administering Danyu He-mai Granules at different concentrations and 0.5％CMC-Na solution by gavage,the mice were continuously observed for 14 days to record their general state,body mass,food consumption,and appearance of major organs,as well as their poisoning and death.Results In the acute toxicity experiment,no poisoning or death was observed in mice in each dose group of Danyu Hemai Gran-ules.There was no significant difference in the general condition,body mass,food consumption,and organ index of mice before and after administration.Conclusion Within the dose range of 9～36 g/kg,Danyu Hemai Granules had no significant effects on the general condition,body mass,food consumption and major organs of mice.The acute toxicity test suggests that the drug has less toxic side effects and good safety,which provides a basis for safe clinical use.
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