首页|Box-Behnken响应面法优化竹沥半夏炮制工艺

Box-Behnken响应面法优化竹沥半夏炮制工艺

The Box-Behnken response surface method to optimize the preparation technology of Succus bambusae pinella preparata

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目的 优化竹沥半夏炮制工艺,为竹沥半夏饮片临方炮制规范化研究提供参考.方法 采用Box-Behnken响应面法设计分析,以浸出物、次黄嘌呤、尿苷、腺嘌呤、鸟苷的综合评分为评价指标,考察竹沥半夏辅料用量、炮制时间、干燥温度等3个因素,对竹沥半夏炮制工艺进行优选,同时对最佳工艺进行验证.结果 竹沥半夏最佳炮制工艺为:每100 g姜半夏,鲜竹沥15 g,炮制时间1 h,干燥温度44℃.结论 该工艺简易可行、竹沥半夏质量稳定可靠,为竹沥半夏的临床应用提供了科学依据.
Objective In order to optimize the preparation technology of Succus bambusae pinella preparata,and so as to provide a reference for the standardized research on the prescription-based processing of Succus bambusae pinella preparata.Method-s Using the Box-Behnken response surface method design and analysis,taking the comprehensive scores of extractable,hypo-xanthine,uridine,adenine and guanosine as the evaluation index,the three factors of excipient dosage,drying temperature and processing time of Succus bambusae pinella preparata were investigated,and the preparation technology of Succus bambusae pinel-la preparata was optimized,and the best process was used to verify it.Results The best conditions for the preparation technology of Succus bambusae pinella preparata were 100 g of Pinelliae Rhizoma Praeparatum cum Zingibere et Alumine,the fresh bamboo sap was 15 g,the processing time was 1 h,and the drying temperature was 44℃.Conclusion The preparation technology is sim-ple and feasible,and the quality of Succus bambusae pinella preparata is stable and reliable,which provides a scientific basis for the clinical application of Succus bambusae pinella preparata.

Succus bambusae pinella preparataBox-Behnken response surface methodologyProcessing technologyOverall desirability value

罗美美、朱伟豪、郑琳玉、朱星宇、梅春梅、陈富贵、赵雨薇、郝芳雨、胡晓芳、李伟东

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南京中医药大学药学院,江苏南京 210023

江苏省中药炮制重点实验室,江苏南京 210023

竹沥半夏 Box-Behnken响应面法 炮制工艺 总评归一值

中央财政转移支付地方项目(2022)

2024

时珍国医国药
时珍国医国药杂志社

时珍国医国药

北大核心
影响因子:0.887
ISSN:1008-0805
年,卷(期):2024.35(2)
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