Investigation on the effect of Xiangsha Liujunzi Decoction on serum cytokines in patients with dyslipidemia due to spleen deficiency based on Bio-plex suspension chip technology
Objective To investigate the effect of Xiangsha Liujunzi Decoction on serum cytokines in patients with dyslipidemia due to spleen deficiency.Methods According to the corresponding standards,25 patients with dyslipidemia(disease group)were selected and given Xiangsha Liujunzi Decoction for 4 weeks,and 25 patients in the control group were healthy physical exami-nees.Bio-Plex suspension microarray technique was used to detect the levels of 12 cytokines in serum samples of each group.Results Compared with the control group,the serum levels of six kinds of cytokines in the disease group were significantly lower,which were IL-7,IL-8,G-CSF,MCP-1,MIP-1b and TNF-α,and the differences were statistically significant(P＜0.05).Compared with the disease group,the serum levels of IL-7,IL-8,G-CSF,McP-1,MIP-1B and TNF-α in the treatment group were significantly increased,and the differences were statistically significant(P＜0.05).Conclusion Bio-plex suspension chip was used for detection,and various immune imbalances were found in patients with dyslipidemia.Treatment with Xiangsha Liujunzi Decoction can correct this imbalance and improve the obstruction of cream fat transfer in the state of spleen deficiency,so as to prevent and treat dyslipidemia.
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