Ameliorative effect of kudzu powder on the disorder of glucose and lipid metabolism in mice
Objective Explore the improvement effect of long-term intake of Pueraria on chronic inflammation and glycolipid metabolism disorder.Methods 36 C57BL/6J mice were randomly divided into blank group,control group and kudzu powder group,with 12 mice in each group.Based on the chronic inflammation and glycolipid metabolism disorder mice model which was established by feeding high-fat diet and dextran sulfate sodium.kudzu powder group was gavage with 5g/kg body weight(BW)of kudzu powder,and the other two groups were gavage with the same amount of normal saline.The weight of mice in each group was measured weekly and the disease activity index was scored.After 15 weeks,the fasting blood glucose and glucose tolerance of mice were measured.The colon length,liver and fat weight of mice were measured.The serum TG,TC,HDL-C and LDL-C levels of mice were measured by the kit.Based on the above experimental results,the improvement effect of kudzu powder on chronic inflammation and glycolipid metabolism disorder in mice was evaluated.Results The body weight of mice increased abnor-mally and rapidly after feeding high-fat diet and DSS,and the growth rate decreased after the intervention of kudzu powder diet.Compared with the blank group,the disease activity index score of the control group was significantly higher,the colon was short-ened,and the weight of liver and adipose tissue was significantly increased.Compared with the control group,all relevant indica-tors were significantly improved after the intervention of kudzu powder diet.These results showed that that kudzu powder diet in-tervention can alleviate the intestinal inflammation of mice,inhibit the abnormal weight growth of mice,and improve the lipid me-tabolism of liver and adipose tissue.Compared with the blank group,the fasting blood glucose,glucose tolerance,serum TG,TC,LDL-C levels in the control group were significantly increased,while the glucose tolerance and HDL-C levels were signifi-cantly decreased.Compared with the control group,all indicators of the intervention group were improved.These experimental re-sults showed that kudzu powder diet intervention can reduce blood glucose,improve glucose tolerance and improve blood lipid in mice.Conclusion Kudzu powder may have a potential role in preventing prevent chronic inflammation and disorder of glucose and lipid metabolism to a certain extent,which may be related to the regulation of glucose and lipid metabolism and improvement of in-testinal inflammation by resistant starch and isoflavones in Kudzu powder.
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