Study on Chemical Constituents and Antibacterial Activity of Stelleropsis tianschanica(Pobed)
Objective To study the chemical constituents of Stelleropsis tianschanica(Pobed),a Thymelaeaceae plant.Methods Using column chromatography to separate and purify the pure methanol extract of Stelleropsis tianschanica(Pobed)and the struc-ture of the compound was rationalized and identified using nuclear magnetic resonance NMR and high-resolution mass spectrome-try.The filter paper method was used to screen the antibacterial activity of monomeric compounds at different concentrations.Re-sults Eight compounds were obtained and identified as(E)-11-methoxy-11-oxoundec-2-enoic acid(1)、Methyl-(E)-9-oxooctadec-10-enoate(2)、3-Hydroxyphthalimide(3)、Dimethyl hexadecanedioate(4)、Octadecane-1,18-dimethyl-ester(5)、9-methoxy-9-oxononanoic acid(6)、n-Hcxadecane acid(7)、Bothrioclinin(8)、Daphnolon(9)、β-sitostcrol(10)、Sesamin(11).Compound 7(128 μg/ml)had some inhibitory activity against Staphylococcus aureus,with a size of 8.65mm of the antibacterial ring,and compound 9(128 μg/ml and 64 µg/ml)had inhibitory activity against Acinetobacter bau-mannii,with antibacterial ring of 12.65 mm and 8.05 mm.Conclusion Compounds 1～9 were obtained from this plant for the first time and the 13 C-NMR data of compounds 1～3 were reported for the first time.Compounds 7 and 9 showed certain antimicrobial activity.
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