首页|基于基准关联度和AHP-熵权法优化经典名方达原饮的提取工艺

基于基准关联度和AHP-熵权法优化经典名方达原饮的提取工艺

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目的 评价现代工艺与传统工艺产品质量的一致性,基于基准关联度和层析分析法(AHP)-熵权法优选经典名方达原饮的提取工艺。方法 在遵古原则的基础上,以槟榔碱、厚朴酚、和厚朴酚、黄芩苷含量及指纹图谱相似度和出膏率为评价指标,引用基准关联度评价工艺产品质量一致性,用AHP-熵权法确定指标权重系数,结合正交试验优选经典名法达原饮的提取工艺参数并验证。结果 基准关联度结合层次分析-熵权法优选出的达原饮最佳提取工艺为加水量8倍,提取1次,每次1h。结论 筛选出达原饮现代提取工艺参数具有可行性,为经典名法达原饮复方制剂的开发研究奠定基础。
Optimization of the extraction process of the classic prescription Dayuanyin was optimized based on the standard relation and AHP-entropy weight method
Objective The consistency of modern process and traditional process product quality was evaluated.Based on the standard relation and the analytic hierarchy process(AHP)-entropy weight method,the extraction process of the classic pre-scription Dayuanyin was optimized.To optimize the extraction process of the classic prescription Dayuanyin.Methods On the ba-sis of the principle of following the ancients,the contents of arecine,honokiol,and honokiol,baicaLin,scutellin and fingerprint similarity and paste yield were taken as the evaluation index,and the standard relation was used to evaluate the consistency of process product quality,and the index weight coefficient was determined by analytic hierarchy method(AHP)-entropy weight method,and the extraction process parameters of the classic prescription Dayuanyin were selected and verified by orthogonal test.Results The optimal extraction process of Dayuanyin by the standard relation combined with AHP-entropy weight method was 8 times the amount of water added and extracted once for 1h each time.Conclusion It is feasible to screen out the modern extrac-tion process parameters of Dayuanyin,which lays a foundation for the development and research of the compound preparation of the classic prescription Dayuanyin.

DayuanyinExtraction processStandard relationAnalytic hierarchyEntropy weight law

张荣华、靳梓微、邱智东、李银清

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长春中医药大学药学院,吉林长春 130117

达原饮 提取工艺 基准关联度 层次分析法 熵权法

2024

时珍国医国药
时珍国医国药杂志社

时珍国医国药

北大核心
影响因子:0.887
ISSN:1008-0805
年,卷(期):2024.35(3)