Analytic hierarchy process-Orthogonal test-Multi-index comprehensive evaluation method optimization of Xianxiong Gukang particles extraction process
Objective To study and establish the best extraction process of Xianxiong Gukang particles.Methods The orthogonal test was used to investigate the effects of extraction times,solid-liquid ratio and extraction time on the extraction process.Taking icariin,epimedin C,baohuoside I,ferulic acid,oleanolic acid,cinnamic aldehyde transfer rate as evaluation index,and the ana-lytic hierarchy process to determine the components weight coefficient(weight coefficients were 0.35,0.14,0.09,0.2,0.13,0.09),and adopts multi-wavelength switching and gradient elution technology to establish a HPLC method for the determination of the above six components in Xianxiong Gukang liquid medicine;The multi-index comprehensive weighted evaluation method was used to determine the best extraction process,and three batches of validation tests were carried out.Results The factors influ-encing the efficiency were,in order,extraction time,extraction times and solid-to-liquid ratio.The best extraction process was that extracted by 10 times of 50％ethanol twice and 60 mins per time.Conclusion The optimized extraction process of Xianxiong Gukang can completely extract the effective components,and the method is stable and reproducible,which is suitable for quality control of industrial production.
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