Proteomic study of Tuina on the colon of the experimental colitis mice
Objective To explore the therapeutic effect and mechanism of Tuina on experimental colitis mice.Methods Eighteen male BALA/c mice were randomly divided into the normal,model,and tuina groups.The experimental colitis model was induced by dextran sodium sulfate(DSS)in the model and Tuina group.The Tuina group was intervened 7 d after modeling,and the gen-eral conditions such as body weight and blood stool were recorded during the experiment.After 7 interventions,colon tissues were taken for HE staining and proteomics study.Results The general condition of UC mice improved after Tuina interventions,and HE staining showed a reduced degree of colon tissue pathologies.The proteomic results showed a total of 216 differential proteins associated with the effect of Tuina,402 metabolic pathways identified by iPath analysis,and 262 pathways enriched by KEGG a-nalysis.Conclusion China can improve the inflammatory symptoms of UC,and its action mechanism may be related to vitamin digestion and absorption,arachidonic acid metabolism,and regulation of inflammatory mediators by TRP channels.
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