Effects of Platycodonis Radix on the chemical constituents of Qinbai Qingfei Concentrated Pills in the lung tissues by UPLC-Q-TOF-MS
Objective To make a comparison of changes of constituents in the lung tissues between Qinbai Qingfei Concentrated Pills(QQCP)and lacked Platycodonis Radix of QQCP to explore the effect of Platycodonis Radix as a channel ushering drug in the Chinese herbal compound QQCP.Methods Rats were given intragastric administration of QQCP and lacked Platycodonis Radix of QQCP,and then collected the lung tissues.Using the technology of UPLC-Q-TOF-MS to carry out the determination in posi-tive and negative ion scanning mode.Find the different ions in the samples between the groups by principal component analysis u-sing the software of MarkerView 1.2.1.Meanwhile,identify different compounds and analyse auantivatively on the basis of infor-mation,including retention time,first order mass spectrum,second order mass spectrum and elementary composition combined with the software of PeakView 2.0/masterview 1.0.Results In the comparion of chemical component absorbed into the lung tissues,eight relatively higher compounds with significant differences were found between two groups.Conclusion Platycodonis Radix could increase the distribution of effective constituent of QQCP in lung tissues as a channel ushering drug.
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