Effect of HT7 and SP6 acupoint compatibility on clinical symptoms and serum 5-HT and GABA of insomnia patients with different main symptoms
Objective To observe the effect of HT7 and SP6 on clinical symptoms of insomniacs and the regulation mechanism of serum 5-HT and GABA.Methods 90 insomnia patients meeting the diagnostic criteria were randomly assigned to HT7 group,SP6 group and HT7-SP6 group at 1∶1∶1,with 30 cases in each group.The use of electroacupuncture HT7 single point,electroa-cupuncture SP6 single point,electroacupuncture HT7-SP6 double point,the treatment time is 30min,the treatment is carried out 1 times a day,5 days for a course of treatment,a total of 2 courses of treatment,the rest between courses of 2 days.Measure yourself medical outcomes profile(MYMOP)was used to evaluate the severity of clinical symptoms in each group before and after treatment.Meanwhile,insomniacs were further divided into mainly nocturnal symptoms and mainly daytime symptoms according to the symptom classification of MYMOP scale.The Sleep dysfunction rating scale(SDRS)and Epworth sleepiness score(ESS)were used to evaluate the sleep quality at night and the degree of daytime fatigue and lethargy in insomnia patients with different main disorders.Meanwhile,the serum 5-HT and GABA contents of patients were detected to reveal the mechanism of HT7 and SP6.Results ① MYMOP score of all groups decreased after treatment(P＜0.05),and MYMOP score of SP6 group and HT7-SP6 group was significantly lower than that of HT7 group(P＜0.05).Among the 90 patients with insomnia,52 cases had noc-turnal symptoms and 29 cases had daytime symptoms.② The SDRS scores of all groups with nocturnal symptoms were decreased after treatment,and SDRS scores of SP6 group and HT7-SP6 group were lower than HT7 group after treatment(P＜0.05).The serum GABA content in HT7 group was significantly increased(P＜0.05),the serum 5-HT content in SP6 group was in-creased(P＜0.05),the serum 5-HT and GABA contents in HT7-SP6 group were significantly increased(P＜0.05),and the serum 5-HT content in HT7-SP6 group was significantly higher than that in HT7 group(P＜0.05).③ ESS scores in SP6 group and HT7-SP6 group were significantly decreased after treatment,while serum 5-HT and GABA contents were significant-ly increased in acupoint combination group(P＜0.05).Compared with other groups,the ESS score of HT7-SP6 group was lower than that of HT7 group after treatment(P＜0.05).Conclusion ①The compatibility of HT7-SP6 can significantly im-prove the quality of sleep at night in insomniacs with nocturnal symptoms,and significantly improve the degree of daytime fatigue and sleepiness in insomniacs with daytime symptoms.(2)SP6 plays a leading role in the development of acupoint compatibility effect.③The upregulation of serum 5-HT and GABA by electroacupuncture may be an important mechanism for the compatibili-ty effect of HT7 and SP6.
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