Clinical Study on the Influence of Traditional Chinese Medicine's Cold and Damp Syn-drome Elements on the Clinical Symptoms of Knee Osteoarthritis Patients
Objective This study aims to investigate the relationship between Traditional Chinese Medicine(TCM)cold and damp syndromes elements and the clinical symptoms of Knee Osteoarthritis(KOA).Methods Utilizing a cross-sectional study design,we examined 110 KOA patients who visited the Department of Orthopedics at Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine from March to November 2015,based on data from the earlier FHS clinical cohort.A-mong the participants,there were 23 males and 87 females with an average age of 60.67±6.01 years and an average Body Mass Index(BMI)of 23.79±2.88 kg/m2.Based on the diagnostic criteria of"Syndrome Element Differentiation",patients were categorized into cold,damp,and combined cold+damp syndrome groups.Clinical symptoms were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC).Comparisons of WOMAC scores were made among cold vs.non-cold,damp vs.non-damp,and cold+damp vs.non-(cold+damp)groups.Multivariate regression analyses were em-ployed to examine the association of cold,damp,and cold+damp syndromes with WOMAC scores.Results Compared to patients without syndrome diagnoses,those diagnosed with cold,damp,or combined cold+damp syndromes exhibited significantly elevat-ed WOMAC scores(P＜0.05).Regression analyses revealed that after adjusting for gender,age,BMI,and disease duration,cold syndrome had a significant positive effect on all WOMAC scores(pain:β=4.582,t=2.879,P=0.005;stiffness:β=1.558,t=1.994,P=0.049;function:β=15.324,t=3.146,P=0.002;total:β=21.464,t=3.302,P=0.001).Damp syndrome significantly affected only WOMAC function and total scores(function:β=10.942,t=2.016,P=0.046;total:β=14.950,t=2.056,P=0.042).When both cold and damp syndromes were present,significant effects were observed across all WOMAC scores(pain:β=3.750,t=2.357,P=0.020;stiffness:β=2.229,t=2.953,P=0.004;function:β=14.146,t=2.923,P=0.004;total:β=20.125,t=3.120,P=0.002).Conclusion TCM cold and damp syndromes have a significant association with the clinical symptoms of KOA patients,suggesting that interventions targeting these TCM syndromes could have positive implications for the prevention and management of KOA.
Traditional Chinese Medicine Syndrome ElementsTraditional Chinese Medicine Diagnostic TheoryOsteoar-thritisKnee Osteoarthritis
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