Comparative Study on the Pharmacodynamics of Erchen Tang Modified Formula Break-ing Wall Decoction and Traditional Decoction in Treating Phlegm Syndrome in Rats with Metabolic Syndrome
Objective Compare the effects of Erchen Tang's modified formula and traditional decoction pieces on blood glucose,blood lipids,blood pressure,and other related indicators in rats with metabolic syndrome induced by a high-fat,high sugar,and high salt diet.Methods After one week of adaptive feeding of Wistar rats,one group was reserved as a blank group,and the re-maining rats replicated the metabolic syndrome rat model through a high-fat,high sugar,and high salt diet.After modeling,the model group was randomly divided into MS group,traditional decoction piece group,broken wall decoction piece group,broken wall decoction piece 1/2 dose group,broken wall decoction piece 1/4 dose group,broken wall decoction piece 1/8 dose group,and metformin group.Corresponding drugs were given to each group,while the blank group and MS group were given physiologi-cal saline by gavage for 4 weeks.Measure the weight,length,and blood pressure of rats in each group,and calculate Lee's obesi-ty index;Detect serum triglycerides(TG),total cholesterol(TC),low-density lipoprotein(LDL-C),and high-density lipo-protein(HDL-C);Measure fasting blood glucose(FBG),fasting insulin(FINS),and calculate insulin resistance index(HO-MA-IR);HE staining method was used to observe the pathological morphological changes of rat liver tissue.Results Compared with the MS group,the traditional decoction group showed a decrease in Lee's obesity index and blood pressure,as well as an im-provement in various biochemical indicators and insulin resistance.Compared with the traditional decoction group,the improve-ment of blood glucose,blood lipids,blood pressure and other related indicators in rats was more significant when treated with the same dose and concentration of broken wall decoction.The therapeutic effect of the 1/2 dose group of broken wall decoction on MS rats was similar to that of the traditional decoction group.Conclusion Both the broken wall decoction pieces and traditional decoc-tion pieces of Erchen Tang can improve related indicators such as blood sugar,blood lipids,and blood pressure in MS rats,and the effect of broken wall decoction pieces is better than that of traditional decoction pieces.
Metabolic syndromeErchen TangBreaking Wall DecoctionModified Formula
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