Effect of different transdermal absorption promoters and combinations on the absorption effect of nicotinamide gal
Objective To study the effect of different transdermal absorption promoters and combinations on the transdermal ab-sorption effect of nicotinamide gal.Methods Franz diffusion cell was used for in vitro osmotic experiment.The abdominal skin of mice was used as the test skin.The concentration of nicotinamide in the receiving solution was determined by UV spectrophotome-try,and the cumulative release amount of nicotinamide(Q)was calculated.Research the effect of laurocapram,diethylene glycol monoethyl ether,DMSO,eucalyptus oil,clove volatile oil and combined transdermal absorption promoters..Results Q of nicotin-amide gel with the best Single transdermal absorptions were 1％ Laurocapram(493.23±32.74)μg·cm-2,1％ Diethylene glycol monoethyl ether(607.14±37.79)μg·cm-2,2％ DMSO(657.6±39.37)μg·cm-2,1％ eucalyptus oil(684.26±30.86)μg·cm-2,1％ clove volatile oil(714.83±42.92)μg·cm-2,1％ eucalyptus oil+1％ clove volatile oil(689.38±34.45)μg·cm-2.Conclusion Single and combined both have the effect of transdermal absorption,among all transdermal absorption promot-ers 1％ clove volatile oil has the best effect.
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