The clinical observation of Xiaoyou decoction in treating HR-HPV infection related LSIL and its influence on vaginal microecology
Objective To observe the clinical effect of Xiaoyou decoction in treating damp-heat type Human Papilloma Virus(HR-HPV)infection related Low-grade Squamous Intraepithelial Lesion(LSIL)and its influence on Vaginal Microecology(VM).Methods 90 patients from January 2022 to December 2022 were randomly divided into experimental group and control group,with 45 patients in each group.The experimental group was given vaginal lavage with Xiaoyou decoction,and the control group was applied recombinant human interferon α-2b gel to vagina.The treatment period was 3 months.After 30 days,observe the HR-HPV negative conversion rate,the recovery of TCT,TCM syndrome scores and VM changes were compared between the two groups,and adverse safety events were recorded.Results The HR-HPV negative conversion rate was 64.29％,which was higher than the control group at 40.00％(P＜0.05).The HR-HPV negative conversion rate was 64.29％,which was higher than the control group at 40.00％(P＜0.05),and the TCT recovery rate was 71.43％,which was higher than the control group at 42.50％(P＜0.05).The TCM syndrome scores of both groups decreased significantly after treatment(P＜0.01).The VM recovery rate of the experimental group was 30.95％,which was significantly higher than the control group at 10％(P＜0.05).Moreover,the diversity of flora,leukocytes,hydrogen peroxide,pH and leukocyte esterase in the experimental group after treatment were lower than those in the control group(P＜0.05).Conclusion Xiaoyou Decoction has significant efficacy in the treatment of damp-heat type HR-HPV infection related LSIL at clearing HR-HPV,restoring TCT to normal,improving clinical symptoms of traditional Chinese medicine,and restoring vaginal microecology.
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