Effect of Bushen Yangxue prescription on senile knee osteoarthritis
Objective To observe the effect of Bushen Yangxue prescription on senile knee osteoarthritis(KOA).Methods A to-tal of 106 elderly patients with moderate and severe KOA admitted to our hospital from October 2019 to December 2022 were se-lected as the study objects and divided into two groups according to medication regimen.Both groups were given arthroscopic cleaning treatment,and the control group was injected with sodium hyaluronate 24 hours after operation.Yangxue prescription group was treated with Bushen Yangxue prescription on the basis of control group,and the therapeutic effect of the two groups was compared.Results Compared with before treatment,knee extension motion decreased after treatment,and knee flexion motion in-creased after treatment,but there was no statistical difference after treatment(P＞0.05).Compared with before treatment,serum interleukin-17(IL-17),tumor necrosis factor-α(TNF-α)and CC chemokine ligand 18(CCL18)in 2 groups were de-creased after treatment,and Yangxue prescription group was lower than control group(P＜0.05).Serum transforming growth fac-tor β1(TGF-β1)was increased in both groups after treatment,and Yangxue formula group was higher than control group(P＜0.05).Compared with before treatment,the synovial thickness and joint effusion thickness of the two groups decreased after treat-ment,and the Yangxue prescription group was lower than the control group(P＜0.05).Compared with before treatment,TCM symptom score,visual analogue scale(VAS)score and osteoarthritis index scale(WOMAC)score of two groups were decreased after treatment,and Yangxue prescription group was lower than control group(P＜0.05).The lower limb Fugl-Meyer(FMA)score of the two groups was increased after treatment,and the Yangxue formula group was higher than the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Bushen Yangxue decoction can promote the absorption of inflammation,improve the motion of knee joint and promote the recovery of knee joint function in the treatment of senile moderate and severe KOA.
Tonifying kidney and nourishing blood formulaArthroscopeKnee osteoarthritisKnee joint functionKnee range of motion
NETL
NSTL
万方数据
