Discussion on the Influence of Japonica Rice on the Physicochemical Properties of Famous Classical Formulas Compound Preparation with Xiebai San for Example
Objective This paper will take Xiebai San as an example to compare the similarities and differences of the physical and chemical properties of the decoction obtained by adding or reducing japonica rice,so as to provide a basis for the selection of japonica rice in the development of the ancient famous classical formulas prescription compound preparation.Methods Characterization of the effect of japonica rice on the chemical properties of the decoction:1.Determination of the contents of the main chemical components in Xiebai San and japonica rice negative decoction by the established ultra performance liquid chromatography(UPLC)method;2.The fin-gerprint profiles of the two were analyzed for similarity;3.Determine and compare the thermal stability of the main active ingredients of the two according to the established content determination method.Characterization of the effect of japonica rice on the physical properties of the decoction:1.Measuring the dry paste rate of decoction;2.The particle size,zeta potential and conductivity of colloidal phase were determined by laser particle size analyzer;3.Testing the solubility of the decoction lyophilized powder,in order to predict the effect of japonica on the physical properties of the preparation when taking medicine.Results Chemical Properties:The content of main chemical components of Xiebai San decoction was significantly lower than that of japonica rice negative decoction;the UPLC fingerprints of the two were highly similar;and the common peak area of Xiebai San decoction was smaller than that of japonica rice negative decoction;Heating results in a significant decrease in the content of kukoamine B in Xiebai San decoction,while japonica rice has no significant effect on its thermal stability.Physical Properties:The colloidal particle size of japonica rice negative decoction was slightly smaller than that of Xiebai San,and there was no significant difference in zeta potential and conductivity between them;The dry paste rate of Xiebai San was signifi-cantly higher than that of japonica rice negative decoction;and the lyophilized powder japonica rice negative sample had better solubility than that of the lyophilized powder of the Xiebai San powder sample,with less precipitation and insoluble impurities.Conclusion The ja-ponica rice in Xiebai San reduced the dissolution of the main active ingredients,which had no effect on the thermal stability of the main active ingredients during the heating process of the decoction,and increased the content of insoluble matter in lyophilized powder of Xie-bai San.It was suggested that the japonica rice could be removed during the development of famous classic formulas prescription com-pound,"japonica rice water to be taken"should be marked in the drug instructions.
万方数据
维普
