Clinical Observation of Kuoxin Formula in Treatment of Ventricular Remodeling in Patients with Acute Myocardial Infarction
Objective To observe the clinical effect of Kuoxin Formula combined with standard western medicine on ventricular remode-ling in patients with acute myocardial infarction.Methods A total of 100 patients were randomly divided into control group and observa-tion group,50 cases in each.The control group was treated with standard western medicine,and the observation group was treated with Kuoxin Formula on the basis of the control group for 12 weeks.Clinical efficacy,echocardiographic indexes(LVEF,LVEDD,LVESD,IVS,LVPWT),serum NT-proBNP,ST-2,Galectin-3,MMP-9,PICP,IL-6,VEGF,MLHFQ score,Lee's heart failure score,major adverse cardiovascular events,and safety indicators were detected before and after treatment.Results The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the improvement of EF,LVEDD and LVESD in the observation group was better than that in the control group(P＜0.05).Meanwhile,the serum NT-proBNP,ST2,Galectin-3,MMP-9,PICP and IL-6 in the observation group were obviously decreased while the serum of VEGF was increased(P＜0.05).No significant adverse reactions were found in both groups.Conclusion Kuoxin Formula combined with western medicine standard treatment can safely and effectively relieve the clinical symptoms of patients with myocardial infarction and improve ventricular remodeling.
Kuoxin FormulaAcute Myocardial InfarctionVentricular remodelingQi and Yin deficiency combined with blood stasis syndrome
万方数据
维普
