Preparation and evaluation of Psammosilene tunicoids total saponins ethosome gels
Objective To optimize the formulation and preparation technology of Psammosilene tunicoids total saponins ethosomes gels,and to evaluate its quality and safety.Methods The response surface experiment was designed with the comprehensive score as the main evaluation index,and the proportion of carbomer 940,glycerol and propyl glycol as the investigation factors to optimize the prescription of Psammosilene tunicoids total saponins ethosome gels.Evaluate the quality of the best prescription gels,and compared the transdermal performance of ethosome gel with the ordinary gel.And evaluated the drug safety by the rabbit skin irritation experiment.Results The optimal prescription of Psammosilene tunicoids total saponins ethosome gels was carbomer 940 proportion of 1.95％,glycerol proportion of 7.69％and propyl glycol proportion of 5.75％.The prepared ethosome gels gels of Psammosilene tunicoids total saponins were milky white,translucent,and has good physical stability and light stability,the average comprehensive score was 91.0933.The Q12h of Psam-mosilene tunicoids ethosome gels was 118 μg/cm2,The Q12h of Psammosilene tunicoids total saponins gels was 83 μg/cm2.The skin irri-tation test showed that the rabbit skin irritation score was 0,and there were no histopathological changes in the pathological sections.Conclusion The established preparation method of Psammosilene tunicoids total saponins ethosome gels was stable and feasible,and the preparation of Psammosilene tunicoids total saponins ethosome could effectively promote the transdermal performance of drugs.And it had medication safety and the potential for further application in clinical medication.
Psammosilene tunicoids total saponinsEthosomeGelPrescription optimizationQuality evaluationSafety e-valuation
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