Optimization of Guipi Mixture Volatile Oil Inclusion Process Based on Box-Behnken Re-sponse Surface Method
Objective To optimize the inclusion process of Guipi Mixture volatile oil.Methods Inclusion method of Guipi Mixture vola-tile oil was screened with the yield of inclusion compound,inclusion rate of volatile oil-β-cyclodextrin and the content of ligustilide per gram of inclusion compound as indicators,and assigning weight coefficients to each indicator and calculating a comprehensive score.On the basis of single factor test,mass volume ratio of[3-cyclodextrin to volatile oil,mass volume ratio of β-cyclodextrin to water and inclu-sion time as factors,Box-Behnken design-response surface method was used to optimize the technology of Colloid mill inclusion process of Guipi Mixture volatile oil.The influencing factors of volatile oil inclusion compounds were tested,and the production and storage condi-tions were determined.Results The optimum technological conditions was the mass volume ratio of β-cyclodextrin to volatile oil was 10:1,β-CD-pure water ratio was 1:7,and the inclusion time was 40 min.Conclusion The inclusion process of Guipi Mixture volatile oil by response surface method is better.The model can be used in industrial production.
Guipi Mixture Volatile OilLigustilideBox-Behnken response surface methodologyColloid mill inclusion process
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