Digital humanities,as an active promoting force of the Open Agenda,shares the same core values with Open Science:freedom,collaboration,inclusion,sharing,openness,and transparency.Digital technologies not only pro-vide the technical foundation for realizing freedom,openness,and sharing,but they also transformed human thinking and the paradigms of scientific research.The widespread application of emerging technologies,such as artificial intelli-gence,has exerted a significant impact on the disciplinary literacy,research paradigms,and trends of digital humanities.Simon Mahony,Emeritus Professor of Digital Humanities at University College London(UCL),has been active in the field for over 20 years.As a contributor,researcher,and educator in digital humanities,he analyzes the de-velopment of this field from a comprehensive perspective.Through three in-depth interviews with Professor Mahony,this article discusses the spirit of openness in digital humanities,starting from the Open Agenda and Open Science,with a particular focus on the development and future of digital humanities in the era of artificial intelligence.By conducting a comparative analysis of domestic and international discussions surrounding the Open Agenda,this article aims to un-cover the various focal points and its potential development in China,providing new perspectives for digital humanities'spirit of openness and exploring its expansive prospects in the new era.