振幅整合脑电图联合血清HIF-1α、NFP在新生儿脑损伤中的诊断价值
The Diagnostic Value of Amplitude Integrated Electroencephalogram Combined with Serum Hif-1α and NFP in Neonatal Brain Injury
胡娟娟 1何晓娜 1贾圆圆1
作者信息
- 1. 灵宝市第一人民医院,河南 灵宝 472500
- 折叠
摘要
目的:探讨振幅整合脑电图联合血清缺氧诱导因子-1α(HIF-1α)、神经丝蛋白(NFP)在新生儿脑损伤中的诊断价值.方法:选择 2020 年 1 月至 2023 年 1 月灵宝市第一人民医院收治的 76 例足月新生儿缺氧缺血性脑病(HIE)患儿作为观察组,根据脑损伤程度将其分为轻度损伤组(19 例)、中度损伤组(37 例)、重度损伤组(20 例),行振幅整合脑电图(aEEG)监测,并检测血清HIF-1α、NFP水平.并选择同期 50 例健康新生儿作为对照组.采用受试者工作特征(ROC)曲线评估aEEG、HIF-1α、NFP及联合诊断新生儿脑损伤的价值.结果:观察组患儿血清HIF-1α、NFP水平明显高于对照组(P＜0.05).随着脑损伤程度加重,血清HIF-1α、NFP水平随之升高(P＜0.05).经ROC曲线分析,血清HIF-1α诊断新生儿HIE的曲线下面积(AUC)为 0.683(95%CI:0.327～0.973),截断值为764.09 pg·mL-1.血清NFP诊断新生儿HIE的AUC为0.771(95%CI:0.506～0.879),截断值为19.29 ng·mL-1,aEEG、血清HIF-1α和NFP联合诊断新生儿HIE的AUC为0.889(95%CI:0.627～0.995).结论:联合aEEG和血清HIF-1α、NFP在诊断新生儿HIE上具有较高的潜能.
Abstract
Objective To investigate the diagnostic value of amplitude integrated electroencephalogram combined with serum hypoxia inducible factor-1α(HIF-1α)and neurofilament protein(NFP)in neonatal brain injury.Methods A total of 76 full-term neonatal hypoxic-ischemic encephalopathy(HIE)admitted to the First People's Hospital of Lingbao from January 2020 to January 2023 were selected as the observation group.According to the degree of brain injury,they were divided into mild injury group(19 cases),moderate injury group(37 cases)and severe injury group(20 cases).The amplitude-integrated electroencephalography(aEEG)monitoring and serum HIF-1 α and NFP levels were detected.And 50 healthy newborns were selected as the control group.The receiver operating characteristic(ROC)curve was used to evaluate the value of aEEG,HIF-1 α,NFP and the combined diagnosis of neonatal brain injury.Results The levels of serum HIF-1α and NFP in the observation group were significantly higher than those in the control group(P<0.05).With the aggravation of brain injury,the levels of serum HIF-1α and NFP increased(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum HIF-1α in the diagnosis of neonatal HIE was 0.683(95%CI:0.327-0.973),and the cut-offvalue was 764.09 pg·mL-1.The AUC of serum NFP in the diagnosis of neonatal HIE was 0.771(95%CI:0.506-0.879),and the cut-offvalue was 19.29 pg·mL-1.The AUC of aEEG,serum HIF-1α and NFP in the diagnosis of neonatal HIE was 0.889(95%CI:0.627-0.995).Conclusion The combination of aEEG and serum HIF-1α and NFP has high potential in the diagnosis of neonatal HIE.
关键词
新生儿缺氧缺血性脑病/振幅整合脑电图/缺氧诱导因子-1α/神经丝蛋白Key words
Neonatal hypoxic-ischemic encephalopathy/Amplitude-integrated electroencephalogram/Hypoxia inducible factor-1α/Neurofilament protein引用本文复制引用
出版年
2024
NETL
NSTL
万方数据