血清ST2、PI3K在持续性心房颤动患者中的水平及其与左房纤维化的关系

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中文摘要：目的:探讨血清生长刺激表达基因 2 蛋白(ST2)、磷脂酰肌醇 3 激酶(PI3K)在持续性心房颤动患者中的水平及其与左房纤维化程度的关系。方法:选择 2019 年 6 月至 2023 年 6 月新乡市第一人民医院收治的 100 例持续性心房颤动患者，根据左房电压基质标测将其分为无左房纤维化组(心内膜电压振幅＞0。5 mV，53 例)与左房纤维化组(心内膜电压振幅＜0。5 mV，47 例)。比较两组间临床特征指标的差异，分析血清ST2、PI3K与临床特征指标之间的相关性;并分析左房纤维化的独立危险因素及血清ST2 和PI3K水平对左心纤维化的预测效能。结果:无左房纤维化组与左房纤维化组在年龄、性别、体质量指数(BMI)、左房前后径(LAD)及血清Ⅰ型胶原羧基端前肽(PICP)、Ⅲ型胶原前多肽(PⅢNP)、ST2、PI3K方面比较具有统计学意义(P＜0。05)。相关性分析显示血清ST2 与PI3K无明显相关性(P＞0。05);ST2 与LAD、PICP呈正相关(r=0。681，r=0。572，P＜0。05);PI3K与LAD、LVEDD等指标均无相关性(P＞0。05)。Logistic多因素回归分析显示，年龄、LAD、PICP、ST2、PI3K是左房纤维化的独立预测因素。受试者工作特征(ROC)曲线分析显示血清ST2预测左房纤维化的曲线下面积(AUC)为 0。709，灵敏度为 76。3%，特异度为 62。9%。血清PI3K预测左房纤维化的AUC为 0。633，灵敏度为 67。4%，特异度为 49。6%。结论:血清ST2、PI3K水平与持续性房颤患者左房纤维化的发生有关，二者对左房纤维化的发生无协同性，血清ST2在预测左房纤维化方面更具开发价值。

外文标题：The Expression Levels of Serum ST2 and PI3K in Patients with Persistent Atrial Fibrillation and Their Relationship with the Degree of Left Atrial Fibrosis

外文摘要：Objective To investigate the expression levels of suppression of tumorigenicity 2(ST2)and phosphatidylinositol 3-kinase(PI3K)in patients with persistent atrial fibrillation and their relationship with the degree of left atrial fibrosis.Methods A total of 100 patients with persistent atrial fibrillation from June 2019 to June 2023 at the Xinxiang First People's Hospital were selected and divided into two groups without left atrial fibrosis(endocardial voltage amplitude>0.5mV,53 cases)and left atrial fibrosis(endocardial voltage amplitude<0.5mV,47 cases)according to left atrial voltage matrix mapping.The differences in clinical characteristic indicators between two groups were compared,and the correlation between serum ST2,PI3K and clinical characteristic indicators was analyzed.The independent risk factors for left atrial fibrosis and the predictive power of serum ST2 and PI3K levels for left ventricular fibrosis were analyzed.Results There were significant differences in age,sex,body mass index(BMI),left atrial anterior and posterior diameter(LAD),serum type I collagen carboxy-terminal propeptide(PICP),type III collagen propeptide(PⅢNP),ST2 and PI3K between the group without left atrial fibrosis and the group with left atrial fibrosis(P<0.05).Correlation analysis showed no significant correlation between serum ST2 and PI3K(P>0.05).ST2 was positively correlated with LAD and PICP(r=0.681,r=0.572,P<0.05).PI3K was not correlated with LAD,LVEDD and other indicators(P>0.05).Logistic multiple regression analysis showed that age,LAD,PICP,ST2,and PI3K were independent predictive factors for left atrial fibrosis.The receiver operating characteristic(ROC)curve analysis showed that the area under curve(AUC)of serum ST2 for predicting left atrial fibrosis was 0.709,with a sensitivity of 76.3%and specificity of 62.9%.The AUC of serum PI3K prediction for left atrial fibrosis was 0.633,with a sensitivity of 67.4%and a specificity of 49.6%.Conclusion The levels of serum ST2 and PI3K are related to the occurrence of left atrial fibrosis in patients with persistent atrial fibrillation,and there is no synergy between the two.The serum ST2 has more development value in predicting left atrial fibrosis.

外文关键词：

Persistent atrial fibrillationLeft atrial fibrosisSuppression of tumorigenicity 2Phosphatidylinositol 3-kinase

作者：

李学晋、程希富、魏法权

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作者单位：

新乡市第一人民医院河南新乡 453600

关键词：

持续性心房颤动左房纤维化生长刺激表达基因2蛋白磷脂酰肌醇3激酶

出版年：

2024

DOI：