Objective To investigate the serum levels of heme oxygenase-1(HO-1)and nuclear transcription factor κB(NF-κB)in premature infants with bronchopulmonary dysplasia(BPD)and their relationship with prognosis.Methods Sixty premature infants with BPD(BPD group)and 85 premature infants without BPD(n-BPD group)admitted to Women&Infants Hospital of Zhengzhoul from January 2020 to December 2023 were selected as the study objects.The serum levels of HO-1 and NF-κB at 24 hours,3 days,and 7 days after birth were measured,and their predictive value for BPD was analyzed.According to the prognosis,premature infants with BPD were divided into a good prognosis group(23 cases)and a poor prognosis group(37 cases).The serum levels of HO-1 and NF-κB at 24 hours,3 days,and 7 days after birth were detected and their predictive value for the prognosis of BPD was analyzed.Results The serum level of HO-1 in the BPD group and the n-BPD group continued to increase at 24 hours,3 days,and 7 days after birth,but the serum level of HO-1 in the BPD group was lower than that in the n-BPD group at 3 and 7 days after birth,and the differences were statistically significant(P＜0.05).The serum levels of NF-κB in the BPD group continued to increase at 24 hours,3 days,and 7 days after birth,and were all higher than those in the n-BPD group,with statistically significant differences(P＜0.05).The receiver operating characteristic(ROC)curve analysis showed that the serum levels of HO-1 and NF-κB at 7 days after birth had moderate predictive value for the occurrence of BPD.The serum levels of HO-1 and NF-κB continued to increase at 24 hours,3 days,and 7 days after birth in the good prognosis group and the poor prognosis group.The serum level of HO-1 in the poor prognosis group was lower than that in the good prognosis group at 3 days and 7 days after birth,while the NF-κB level was higher than that in the good prognosis group,and the differences were statistically significant(P＜0.05).The ROC curve analysis showed that the serum level of NF-κB at 7 days after birth had moderate predictive value for the prognosis of BPD.Conclusion The serum levels of HO-1 and NF-κB are associated with the occurrence of BPD in premature infants and have the potential to predict the occurrence of BPD.NF-κB is superior to HO-1 in predicting the prognosis of BPD.
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