A Study on the Feasibility of a Novel Submucosal Filling Agent as an Adjunct to Endoscopic Submucosal Dissection in the Upper Gastrointestinal Tract
Objective To explore the feasibility of a novel submucosal filling agent as an adjunct to endoscopic submucosal dissection(ESD)in the upper gastrointestinal tract.Methods A double-blind,self-controlled study was conducted on 7 experimental pigs.ESD was performed on both the esophagus and stomach of each pig.The control group received submucosal injection of 0.9%sodium chloride solution,while the experimental group received the novel submucosal filling agent.After the surgery,the pigs were reared for one month,and then endoscopic evaluation was conducted to assess the healing of the esophageal and gastric wounds.Subsequently,the esophageal and gastric wounds were dissected for pathological evaluation.The primary outcomes observed and compared between the two groups included operation time per unit area of the wound,complications,and wound healing.Results There was no statistically significant difference in the operation time per unit area of the gastric wounds between the two groups(P＞0.05).The operation time per unit area of the esophageal wounds in the experimental group was significantly shorter than that in the control group,with a statistically significant difference(P＜0.05).At the one-month follow-up,2 cases of postoperative complications were observed in both groups,with no statistically significant difference(P＞0.05).There was no statistically significant difference in the wound healing grade between the two groups(P＞0.05).Conclusion The novel submucosal filling agent can accelerate the ESD procedure for the esophagus,shorten the operation time,and does not increase the incidence of complications or affect wound healing.However,it does not improve the speed of ESD for the stomach.
Submucosal filling agentEndoscopic submucosal dissection of the upper gastrointestinal tractAnimal experimentExperimental pig
万方数据
维普
