The Effect of Carbamazepine on Newly Diagnosed Partial Epilepsy and Its Influence on TLR-4 and NF-κB
Objective To analyze the efficacy of carbamazepine(CBZ)in the treatment of patients with newly diagnosed partial epilepsy and its effect on serum toll-like receptor 4(TLR-4)and nuclear factor-κB(NF-κB)levels.Methods Eighty-one patients with newly diagnosed partial epilepsy in Nanyang Central Hospital(selected from March 2022 to November 2023)were divided into an observation group(41 cases)and a control group(40 cases)by coin toss method.The control group was treated with topiramate,and the observation group was additionally treated with CBZ on the basis of the control group.The clinical efficacy,TLR-4,NF-κB levels before and after treatment and the occurrence of adverse reactions during treatment were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).At 3 months after treatment,the levels of TLR-4 and NF-κB in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion CBZ has a good effect on patients with newly diagnosed partial epilepsy,and can help to reduce the levels of TLR-4 and NF-κB in the serum of patients,and the drug is safe.
万方数据
维普
