Preparation and Properties of TiO2-doped Boron-containing Bioactive Glass Bone Scaffolds
Boron-containing 45S5 bioactive glasses with different doping contents of TiO2(0-8 wt.%)were prepared by using melting method.The prepared glasses were ground into powder and uniformly mixed with photosensitive resin and photoinitiator as slurry.Three-dimensional porous bone scaffolds were prepared by using UV curing,3D printing and high-temperature degreasing sintering technology.X-ray diffractometer(XRD)and universal testing machine were used to test and analyze the scaffolds,while scanning electron microscope(SEM)was used to observe the scaffolds before and after soaking in simulated body fluid(SBF).The effects of TiO2 doping on mechanical and biological properties of the scaffolds were studied.The TiO2 was transferred from anatase to rutile with increasing temperature,which effectively improved the mechanical properties of the scaffolds.When the content of TiO2 was 4 wt.%,the compressive strength of the scaffold reached(12.56±1.06)MPa,which meets the strength requirement of bone trabeculae for bone tissue engineering,while the scaffolds have sufficiently high bioactivity.
3D printing45S5 bioactive glassporous bone scaffoldmechanical propertiesbiological activity
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