Study on Dose-effect Relationship of Yangxin Anmian Capsule in Treating Heart-Qi Deficiency
In order aims to study the pharmacological action and dose-effect relationship of Yangxin Anmian capsule in the treatment of heart-qi deficiency.This study establisbed the model of Heart Qi deficiency in mice by the method of"fatigue,hunger combined with the loss of mental energy".The experiment set up blank group,model group,positive drug group,Yangxin Anmian capsule 0.273 g/kg group,0.546 g/kg group,and 0.819 g/kg group.The exhaustive swimming time,tumor necrosis factor(TNF-α),superoxide dismutase(SOD),malondialde-hyde(MDA),creatine kinase(CK)and lactate dehydrogenase(LDH)were measured,to investigate the pharmacological action and dose-effect relationship of Yangxin Anmian capsule in the treatment of heart-qi deficiency.The results showed that compared with the model group,Yangxinanmian capsule 0.273 g/kg group had no significant effect on the exhaustive swimming time,TNF-α,SOD and MDA(P＞0.05),but significantly decreased the levels of CK and LDH(P＜0.05).Yangxinanmian capsule 0.546 g/kg group and 0.819 g/kg group had sig-nificant effect on all indexes(P＜0.05 or P＜0.01),the results showed that the time of swimming exhaustion was prolonged,the levels of TNF-α,MDA,CK and LDH were decreased,and the levels of SOD were increased.Yangxinanmian capsule has a significant pharmacolog-ical effect in treating heart-qi deficiency,and there is a good dose-effect correlation in the range of 0.273 g/kg～0.546 g/kg,and the effect was obvious at the dosage of 0.546 g/kg and 0.819 g/kg.This study provides theoretical reference for the later clinical medication of Yangxin Anmian capsule.
万方数据
维普
