首页|黄芪多糖的提取、分离纯化及药理活性研究进展

黄芪多糖的提取、分离纯化及药理活性研究进展

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黄芪多糖作为黄芪极其重要的活性成分之一,在临床及养殖上应用较为广泛.黄芪多糖本身是一种混合物,其结构复杂,主要为大分子多糖.经研究发现,黄芪多糖具有抗肿瘤、抗病毒、调节血糖、抗氧化和调节免疫等药理作用.黄芪多糖的提取方法包括溶液提取法、微生物发酵提取法、酶提取法和物理辅助提取法等;分离纯化方法有分级醇沉法、层析柱法和大孔树脂吸附法等.本文对黄芪多糖的提取、分离、纯化方法和多种药理活性进行综述,比较不同提取、分离及纯化方法的优缺点,并对黄芪多糖药理活性的作用机制进行探讨,为黄芪多糖的进一步开发研究提供理论依据.
Study on the Extraction,Purification and Pharmacological Activity of Astragalus Polysaccharide
Astragalus polysaccharide is one of the important active ingredients and has been widely used in clinical treatment and aquacul-ture.Astragalus polysaccharide can be used both as medicine and food.It has a complex structure,is a mixture,mainly macromolecular pol-ysaccharides.Some studies have found that Astragalus polysaccharides have pharmacological effects such as anti-tumor,anti-virus,blood sugar regulation,anti-oxidation,and immune regulation.The extraction methods of Astragalus polysaccharides include solution extraction,microbial fermentation extraction,enzymatic extraction,physical-assisted extraction,etc.Separation and purification methods include frac-tional alcohol precipitation,chromatography column method,macroporous resin adsorption method,etc.This article reviews the extraction,separation,purification methods and various pharmacological activities of Astragalus polysaccharides.The advantages and disadvantages of different extraction,separation and purification methods were compared and the mechanism of pharmacological activity of Astragalus polysaccharides was discussed,which provide theoretical basis for further development of Astragalus polysaccharides.

Astragalus polysaccharidesextraction processseparation and purificationpharmacological activitiesmechanism of action

王帅、高世勇、李婉秋

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哈尔滨商业大学药物工程技术研究中心,黑龙江 哈尔滨 150076

黑龙江省肿瘤预防与抗肿瘤药物研究重点实验室,黑龙江 哈尔滨 150076

黄芪多糖 提取工艺 分离纯化 药理活性 作用机制

黑龙江省自然科学基金资助项目2021年哈尔滨商业大学教师"创新"项目支持计划项目中央支持地方高校改革发展基金优秀青年人才项目黑龙江省卫生计生委科技计划黑龙江省教育厅面上项目

LH2021H002LH2021H0022020YQ122017-13212541571

2024

10.16720/j.cnki.tcyj.2022.170

特产研究
中国农业科学院特产研究所,中国农学会特产学会

特产研究

CSTPCD
影响因子：0.331
ISSN：1001-4721
年,卷(期)：2024.46(1)
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