Based on Network Pharmacology and Molecular Docking to Explore the Mechanism of Astragalus Membranaceus-Ligusticum sinense Combination in Treating Scar
To explore the mechanism of the combination of Astragalus membranaceus-Ligusticum sinense in the treatment of scar through network pharmacology.The effective components and their targets of A.membranaceus and L.sinense were screened by TCMSP database.Scar targets were obtained using OMIM,GeneCards and DrugBank databases.The intersection target of A.membranaceus and L.sinense in the treatment of scar was obtained.Cytoscape 3.7.0 software was used to construct TCM-active ingredient-target-disease network.Construct PPI network through STRING database.KEGG enrichment and GO fuction analysis were visualized using Weisheng website.It is verified by molecular docking.A total of 7 active ingredients of L.sinense were screened,which corresponded to 42 targets.There were 20 active ingredients of A.membranaceus,corresponding to 462 targets.There were 2 216 scar targets.The key ingredients of A.membranaceus-L.sinense combination in treating scar include quercetin and kaempferol.The key targets of scar treatment are TP53 and interleukin 6.KEGG enrichment analysis showed that it was mainly related to IL-17 signaling pathway and TNF signaling pathway.Molecular docking showed that the main active components had good stability with the key targets.Based on the analysis of network pharmacology and molecular doc-king verification,this paper shows that A.membranaceus and L.sinense may treat scar through multi-component,multi-target and multi-pathway.
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