Study on the Mechanism of Xinmai'an Tablets in Treating Arrhythmia and Heart Failure with Concept of"Treating Different Diseases with Same Method"Based on Network Pharmacology and Molecular Docking
The study aimed to explore the mechanism of Xinmai'an tablets in the treatment of arrhythmia and heart failure based on network pharmacology and molecular docking.The effective components and the corresponding targets of Xinmai'an tablets were collected by TCMSP,BATMAN-TCM,Swiss Target Prediction and Stitch databases.Targets of arrhythmia and heart failure were found by GeneCards,TTD,OM1M and DrugBank databases.The common targets of targets of Xinmai'an tablets and targets of arrhythmia and heart failure were founded by Cytoscape software.The"active components of traditional Chinese medicine-common targets-diseases"network map of Xinmai'an tablets in treating arrhythmia and heart failure was also constructed using Cytoscape software.The protein-protein interactions network(PPI)of common targets of dieases and effective components was constructed using STRING database,and core targets were ob-tained by analyzing PPI network with Cytoscape software.GO functional enrichment analysis and KEGG pathway enrichment analysis of core targets were conducted by DAVID.The key targets and effective components were verified by molecular docking.A total of 146 active components of Xinmai'an tablets were screened.178 common targets of Xinmai'an tablets in treatment of arrhythmia and heart failure were founded.11 core targets were STAT3,AKT1,IL-6,TNF,MAPK3,TP53,EGFR,HSP90AA1,VEGFA,EDN1 and PPARA,respectively.Key active components were quercetin,kaempferol,luteolin,ginsenoside Rg1,ginsenoside Re,ginsenoside Rb1 and calycosin-7-O-beta-D-glucoside,etc.Key pathway analysis were HIF-1 signaling pathway,TNF signaling pathway and so on.Molecular docking results showed that quercetin,kaempferol,luteolin,ginsenoside Rg1,ginsenoside Re,ginsenoside Rb1,calycosin-7-O-beta-D-glucoside and other compon-ents could be stably docked with STAT3,TNF,IL-6,VEGFA and other targets.Xinmai'an tablets in the treatment of arrhythmia and heart failure with concept of"treating different diseases with same method"was by multi-components,multi-targets and multi-pathways.It pro-vides scientific basis for further study on the effect mechanism of Xinmai'an tablets and exploration of its new clinical application.
Xinmai'an tabletsarrhythmiaheart failuretreating different diseases with same methodnetwork pharmacologymolecular dockingmechanism
万方数据
