Network Pharmacological Analysis of the Mechanism of Shenling Baizhu Powder for"Different Disease with the Same Treatment"on COPD and Flora Imbalance Diarrhea
Based on network pharmacology,explore the main active components,targets and pathways of Shenling Baizhu Powder"different disease with the same treatment"COPD and flora imbalance diarrhea and clarify its potential mechanism.The active components and targets of Shenling Baizhu Powder were screened by TCMSP or TCMID.GeneCards and OMIM-Genemap were used to obtain the targets related to the occurrence and development of COPD and flora imbalance diarrhea,and the intersection targets of"Shenling Baizhu Powder-COPD-flora imbalance diarrhea"were obtained.They were uploaded to the STRING database to draw the protein interaction network and conduct topological analysis,and analyzed the GO function and KEGG pathway enrichment.By using Cytoscape 3.9.1 the active in-gredient-target-pathway action network was constructed.The molecular docking of main active components and key targets was carried out by using SYBYL and others.A total of 441 targets of Shenling Baizhu Powder and 133 common targets of COPD and flora imbalance di-arrhea were obtained;There were 39 intersection targets between drugs and diseases,and key targets such as PTGS2,NOS2,JUN,RELA,TNF were obtained;The results of enrichment analysis showed that Shenling Baizhu Powder may participate in biological processes such as inflammatory response,response to xenobiotic stimulus,response to lipopolysaccharide and response to molecule of bacterial origin,regulate AGE-RAGE signaling pathway and IL-17 signaling pathway to treat COPD and flora imbalance diarrhea.Molecular docking results showed that the key targets had high binding activity with related active components.The effect of Shenling Baizhu Powder on COPD and flora imbalance diarrhea has the characteristics of multi-component,multi-target and multi-channel mechanism,which can provide a basis for the clinical use of Shenling Baizhu powder.
Shenling Baizhu Powderdifferent disease with the same treatmentCOPDflora imbalance diarrheanetwork pharmacology
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