Study on the Preparation Technology and TLC Quality Standards of Lug-en Qingfei Granules
The aim of this study was to optimize the preparation technolagy and establish the quality standards of Lugen Qingfei granules.The process parameters were optimized by single factor test and orthogonal test method using the yield of dry extract as indexes.The thin layer chromatography(TLC)was performed to identify Rhizoma Phragmitis,Radix Platycodonis,Citri Exocarpium Rubrum,Houttuyniae Herba,Eriobotryae Folium.The optimal preparation process of Lugen Qingfei granules was determined by adding 10 times and 8 times of water to all the medicinal materials,decocting twice(soaking for more than 2 hours before the first decoction),each time for 1.5 h.The ob-tained filtrate was concentrated to a relative density of 1.05～1.10(60 ℃)and mixed with an appropriate amount of excipient(the mass ration is)to produce granules with good dissolubility and formability.The results of thin layer chromatography(TLC)showed clear spots,high specificity,and there was no interference when compared with the negative.The preparation process of this product is stable and reliable.The thin layer chromatography of Rhizoma Phragmitis,Radix Platycodonis,Citri Exocarpium Rubrum,Houttuyniae Herba,Eriobotryae Folium showed no interference,with good repeatability and strong specificity.
万方数据
维普
