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中药复杂体系的多组学分析技术研究进展

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中药复杂体系是由多种生物活性成分组成的,这些成分在体内外通过复杂的相互作用发挥着治疗作用。随着科学技术的发展,多组学分析技术已经成为研究中药复杂体系的重要工具。多组学分析技术,包括基因组学、蛋白质组学、代谢组学等,能够全面地揭示中药成分在分子层面的作用机制,为中药的现代化研究和临床应用提供了新的视角和方法。本综述重点总结了中药复杂体系概述,不同组学分析技术的效用,多组学分析技术在中药复杂体系的药效解析、分子层面阐释、疗效及安全性的优势,探明中药学与分子生物学等多学科交叉对中药复杂体系深入发展的优化策略,以促进中药复杂体系的深入发展。
Research Progress on Multi-omics Analysis Technology for Complex Systems of Traditional Chinese Medicine
The complex system of traditional Chinese medicine is composed of multiple bioactive components,which exert therapeutic ef-fects through complex interactions in vivo and in vitro.With the development of science and technology,multi-omics analysis technology has become an important tool to study the complex system of traditional Chinese medicine.Multi-omics analysis techniques,including geno-mics,proteomics,metabolomics,etc.,can comprehensively reveal the mechanism of action of TCM components at the molecular level,and provide new perspectives and methods for the modernisation research and clinical application of TCM.This review focuses on summarising the overview of the complex system of TCM,the utility of different histological analysis techniques,the advantages of multi-omics analysis techniques in the analysis of pharmacodynamics,molecular level elucidation,therapeutic efficacy and safety of the complex system of TCM,and exploring the optimisation strategies of the interdisciplinary intersection of TCM and molecular biology for the in-depth development of the complex system of TCM,in order to promote the in-depth development of the complex system of TCM.

complex system of traditional Chinese medicinemulti-omics analysisgenomicsproteomicsmetabolomics

杨松柏、尹健、侯旭晖

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吉林大学中日联谊医院,吉林 长春 130031

中药复杂体系 多组学分析 基因组学 蛋白质组学 代谢组学

2024

特产研究
中国农业科学院特产研究所,中国农学会特产学会

特产研究

CSTPCD
影响因子:0.331
ISSN:1001-4721
年,卷(期):2024.46(6)