Objective:To systematically evaluate the effects of the first dressing change time after peripherally inserted central catheter(PICC)placement on bleeding at the puncture site and catheter related infection,and to provide evidence for clinical practice.Methods:PubMed,Web of Science,Embase,Cochrane library,CNKI,Wanfang Database,VIP Journal database and China Biomedical Literature Database were searched for randomized controlled trials and cohort trials about the first dressing change after PICC catheterization.The search time limit was from the establishment of the database to June 2023.Two researchers independently screened the literature,extracted data and assessed the risk of bias of the included studies.RevMan 5.4 software was used for Meta-analysis.Results:Eight studies involving 1 874 patients were included.After the first dressing change time was extended to 48 h or 72 h after PICC placement,the incidence of bleeding at the puncture site was reduced compared with the first dressing change at 24 h(RR =0.63,95%CI 0.50-0.80,P =0.000 1),and there was no significant difference in the incidence of catheter related infection between the two groups(RR = 1.36,95%CI 0.73-2.53,P =0.33).When the first dressing change time was extended to48 h compared with72 h,there was no significant difference in the incidence of bleeding(P =0.63)and catheter-related infection(P =0.64)after PICC placement.Conclusion:The first dressing change time after PICC catheterization can be appropriately extended to 48 or 72 h.
peripherally inserted central catheterchange the dressingoozing bloodinfectionMeta-analysis