In order to solve the stress shielding problem of artificial joint prosthesis,an X-type porous titanium alloy scaffold with 70%porosity was designed based on 3D printing technology,and a hydroxyapatite(HA)coating was constructed on the surface of scaffold.The effects of reaction time and different pretreatment methods on the deposition effect of the HA coating were investigated.It is found that the HA coating has the best effect after 12 h of hydrothermal reaction,and acid etching,pre-alkalinization,and pre-calcination treatments.The X-shaped porous Ti6Al4V alloy scaffold with HA coating is co-cultured with mouse MC3T3-E1 cells to evaluate their cytotoxicity,biocompatibility,cell proliferation,and osteogenic ability.The results show that the HA coating can enhance the biocompatibility of porous Ti6Al4V alloy scaffold,making it easier for MC3T3-E1 cells to adhere and spread on the porous Ti6Al4V alloy scaffold.It promotes the deposition of calcium,phosphorus and other elements,thereby enhancing the mineralization ability and improving the osseointegration ability of the scaffold.
关键词
3D打印/钛合金/羟基磷灰石涂层/多孔支架/骨界面
Key words
3D printing/titanium alloy/hydroxyapatite coating/porous scaffold/bone interface
维普
万方数据