Effects of Combined Exercise and Inonotus Obliquus Extract on Glucose and Lipid Metabolism of Diabetic Mice
Objective:This study aims to establish a diabetic mouse model and supplement it with Inonotus Obliquus extract(IOE),in combination with exercise intervention,to explore the impact of the combined intervention on the glucose and lipid metabolism in diabetic mice,and further assess the efficacy of Inono-tus Obliquus extract.Male ICR mice of SPF grade were randomly divided into 5 groups,totaling 40 mice(n=40):Control group(CON group),Diabetic model group(DB group),Inonotus Obliquus extract group(IOE group),Exercise group(EX group),Exercise combined with Inonotus Obliquus extract group(EI group).After the establishment of the diabetic model,the Inonotus Obliquus extract group(IOE group)and the Exercise combined with Inonotus Obliquus extract group(EI group)were injected with Inonotus Obliquus extract intraperitoneally once a day at a dose of 1 500 mg/kg,while the Control group(CON group),the Diabetic model group(DB group),and the Exercise group(EX group)were in-jected with an equal amount of saline.The Exercise group(EX group)and the Exercise combined with Inonotus Obliquus extract group(EI group)underwent treadmill training.The training time was fixed at 5 times per week for a total of 6 weeks.The Inonotus Obliquus extract group,Exercise group,and Exercise combined with Inonotus Obliquus extract group of diabetic mice improved blood glucose concentration,T-CHO,HDL-C,LDL-C,and GSP levels after 6 weeks of intervention,increased the activity of SOD of diabetic mice,reduced MDA levels,improved the levels of CRE and BUN in diabetic mice,regulated fasting insulin levels,increased insulin sensitivity,promoted cellular function repair,played a good regu-latory role in glucose and lipid metabolism,effectively improved the disorder of glucose and lipid metabolism in diabetic mice.The Exercise combined with Inonotus Obliquus extract group showed more significant improvements in serum detection indicators,and the therapeutic effects after intervention were better.
exerciseInonotus Obliquus extractdiabetesglucose and lipid metabolism
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