Clinical application of time target management in intravenous thrombolysis in acute ischemic stroke
Objective:To investigate the clinical application of time target management in intravenous thrombolysis in acute ischemic stroke.Methods:A total of 198 cases of acute ischemic stroke patients admitted to the Department of Emergency,Tianjin Third Central Hospital from January 2021 to January 2024 were randomly divided into the control group and the observation group according to the random number table method,with 99 cases in each group.The control group adopted the conventional emergency care mode,while the observation group adopted the time-target management process.The number of qualified cases of project completion,the time consumed in each link of diagnosis and treatment,the neurological function and the treatment effect after intravenous thrombolysis in the two groups were compared.Results:The number of qualified cases and rates of pre-hospital preparation,CT preparation and thrombolysis preparation in the observation group were higher than those in the control group(χ2=10.057,22.409,19.753,all P<0.01);the time from admission to the emergency room reception(DTP),the time from admission to the CT report(DTI),the time from admission to the lab-oratory diagnostic report(DTL),and the time from admission to the thrombolysis(DNT)were all shorter than those of the control group(t=22.944,13.218,30.415,56.576,all P<0.01).After receiving intravenous thrombolytic therapy for 7 and 30 d,the National Insti-tute of Health stroke scale(NIHSS)score of the observation group was lower than that of the control group(t=2.453,P=0.038;Z=-2.957,P=0.003);after 90 d,the mRS score of the observation group was lower than that of the control group(Z=-6.557,P<0.01);after intra venous thrombolytic therapy,intracranial hemorrhage in the observation group was 2(2.02%)cases,which was lower than that of the control group which was 9(9.09%)cases(χ2=4.717,P=0.030);2(2.02%)cases of cerebral hernia occurred in the observation group,and death in 90 d was 1(1.01%)cases.There were 6(6.06%)cases of cerebral hernia and 4(4.04%)deaths in the control group,the differences were not statistically significant(all P＞0.05).Conclusion:Time target management reduces the time consumed in all aspects of intravenous thrombolysis,increases the number of completed qualified cases,and improves neurological function and treatment out-comes after intravenous thrombolysis.
time target managementacute ischemic strokeintravenous thrombolysisclinical application
万方数据
维普
