The relationship between serum tumor markers and pathological molecular markers of endometrial cancer and clinical pathological features
Objective:To explore the relationship between serum tumor markers and pathological molecular markers of endometrial cancer(EC)and their clinical pathological characteristics.Methods:A retrospective analysis was conducted on 144 cases of primary EC patients admitted in the Department of Gynecology,Tianjin Union Medical Center from January 2018 to February 2024.The relationship between the preoperative serum tumor markers carbohydrate antigen(CA)125,CA199,CA72-4,as well as the postoperative tissue pa-thological molecular markers including estrogen receptor(ER),progestin receptor(PR),tumor suppressor gene(TP53),Ki-67 and their pathological types,staging,degree of differentiation,depth of myometrial invasion,lymphovascular space invasion,and cervical stromal invasion were evaluated.Results:The levels of CA125,CA199,and CA72-4 in patients with stageⅢ-ⅣEC according to the International Federation of Gynecology and Obstetrics(FIGO,2009)surgical-pathological staging were significantly elevated,with sta-tistically significant differences(Z=-3.45,-4.10,-2.41,all P<0.05).Patients with myometrial invasion depth of≥1/2 had significant-ly elevated levels of CA125,with a statistically significant difference(Z=-2.02,P<0.05).The level of CA125,CA199,and CA72-4 showed statistically significant differences among the differentiation grades of endometrioid adenocarcinoma(H=6.07,6.22,10.79,all P<0.05).The area under the curve(AUC)for the combined use of CA125,CA199,and CA72-4 in diagnosing FIGO stages Ⅲ to Ⅳ,with a myometrial invasion depth of≥1/2,were 0.74 and 0.71,respectively.The positive expression rates of ER and PR in endometri-oid adenocarcinoma were significantly higher than those in non-endometrioid adenocarcinoma(χ2=26.84,26.47,both P<0.001).The positive expression rates of ER and PR in EC stagesⅠ-Ⅱwere significantly higher than those in stagesⅢ-Ⅳ(χ2=18.81,12.66,both P<0.05).The positive expression rates of ER and PR in well-differentiated endometrioid adenocarcinoma were significantly higher than those in poorly differentiated endometrioid adenocarcinoma(χ2=18.04,12.62,both P<0.05).The positive expression rates of ER and PR in patients with myometrial invasion depth less than 1/2 were significantly higher than in those with invasion depth of≥1/2(χ2=13.17,12.32,both P<0.05).The positive expression rates of ER and PR in patients without lymphovascular space invasion,cervical stromal in-vasionwere significantly higher than in those with these conditions.The P53 mutation type and Ki-67 expression≥65%showed statisti-cally significant differences among tissue pathological types(χ2=27.13,8.43,both P<0.05),and compared to endometrioid adenocarci-noma,non-endometrioid adenocarcinoma had significantly higher rates of P53 mutation and Ki-67 expression.Conclusion:CA125,CA199,CA724,ER,PR,P53,and Ki-67 are closely related to the high-risk prognostic factors of EC.
万方数据
维普
