Efficacy and safety of 5-HT1A receptor partial agonist in the treatment of functional dyspepsia:a meta-analysis
Objective:To evaluate the clinical efficacy and safety of partial agonists of serotonin receptor 1A(5-HT1A)in the treatment of functional dyspepsia(FD)by meta-analysis.Methods:Published randomized controlled trials(RCT)of 5-HT1A receptor partial ag-onist in the treatment of FD was collected by searching PubMed,Web of Science,CNKI,and other databases.The data were analyzed using RevMan 5.4,and subgroup analysis and stratification analysis were conducted to assess the efficacy and safety of 5-HT1A receptor partial agonists on FD.Results:A total of 19 RCTs involving 1 575 patients were included,with 801 patients in the treatment group and 774 patients in the control group.Meta-analysis showed the total effective rate of the treatment group was higher than that of the control group(OR=4.18,95%CI:3.05-5.73,P<0.000 01),while the gastrointestinal symptom score(SMD=-1.30,95%CI:-1.95--0.64,P=0.0001),anxiety state score(SMD=-1.22,95%CI:-1.79--0.65,P<0.0001),and depression state score(SMD=-1.52,95%CI:-2.41--0.63,P=0.000 8)were lower than those of the control group.The incidences of sleepiness(OR=4.78,95%CI:1.80,-12.70,P<0.05)and xerostomia(OR=3.07,95%CI:1.31-7.19,P<0.05)were higher than those of the control group.Conclusion:Compared with con-ventional or placebo therapy,the combined application of 5-HT1A receptor partial agonist therapy can improve the overall efficacy;however,only the incidences of sleepiness and xerostomia are relatively high.
万方数据
维普
