Study on synthesis technology of high viscosity acrylic resin for drug delivery
Objective:To prepare Polyacrylic Resin Ⅱ for drug delivery and to investigate the quality of it.Methods:Polyacrylic Resin Ⅱ was prepared by the solution polymerization using methyl methacrylate and methyl acrylic acid as raw material,and benzoyl peroxide as initiator.The effects of solvent mass fraction,initiator concentration and reactive temperature on viscosity and yield of the title complex were studied.Results:The target product Conform to the standards Chinese Pharmacopoeia through a variety of characterization.Conclusion:Under the optimum conditions,the synthesis of medicinal acrylic resin Ⅱ viscosity greater than 20 and less than 50 mPa.S,yield reached 89％.
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