天津化工2024,Vol.38Issue(1) :40-43.DOI:10.3969/j.issn.1008-1267.2024.01.013

药用高粘度丙烯酸树脂合成研究

Study on synthesis technology of high viscosity acrylic resin for drug delivery

许同桃
天津化工2024,Vol.38Issue(1) :40-43.DOI:10.3969/j.issn.1008-1267.2024.01.013

药用高粘度丙烯酸树脂合成研究

Study on synthesis technology of high viscosity acrylic resin for drug delivery

许同桃1
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作者信息

  • 1. 连云港职业技术学院医药与化学工程学院,江苏连云港 222006
  • 折叠

摘要

目的:药用高粘度丙烯酸树脂Ⅱ的合成与表征.方法:以甲基丙烯酸甲酯与甲基丙烯酸为原料,过氧化苯甲酰为引发剂,通过溶液聚合,制备药用高粘度丙烯酸树脂;通过考察了溶剂浓度、引发剂用量以及反应温度等对目标产物粘度和收率的影响,优化了制备工艺.结果:合成的目标产物通过多种表征,符合中国药典标准.结论:在优化的工艺条件下,合成药用丙烯酸树脂Ⅱ粘度在 20~50 mPa·S,收率达到89%.

Abstract

Objective:To prepare Polyacrylic Resin Ⅱ for drug delivery and to investigate the quality of it.Methods:Polyacrylic Resin Ⅱ was prepared by the solution polymerization using methyl methacrylate and methyl acrylic acid as raw material,and benzoyl peroxide as initiator.The effects of solvent mass fraction,initiator concentration and reactive temperature on viscosity and yield of the title complex were studied.Results:The target product Conform to the standards Chinese Pharmacopoeia through a variety of characterization.Conclusion:Under the optimum conditions,the synthesis of medicinal acrylic resin Ⅱ viscosity greater than 20 and less than 50 mPa.S,yield reached 89%.

关键词

聚丙烯酸树脂Ⅱ/制备/高粘度

Key words

polyacrylic resin Ⅱ/synthesis/high viscosity

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基金项目

江苏省青蓝工程优秀教学团队建设项目()

出版年

2024
天津化工
天津市化工科技信息研究所

天津化工

影响因子:0.214
ISSN:1008-1267
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